TP53 Arg72Pro and CCND1 A870G Polymorphisms and Esophageal Cancer Risk

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Show simple item record Berzhan K. Kurmanov Leyla Djansugurova Rakhmetkazhi Bersimbai Azat Shibanova Shunichi Yamashita Vladimir Saenko Natallia Akulevich 2013-04-30T05:19:53Z 2013-04-30T05:19:53Z 2013-04-30
dc.description ru_RU
dc.description.abstract The authors examined 184 residents from Kazakhstan to reveal an association of the CCND1 gene A870G and TP53 gene Arg72Pro polymorphisms with esophageal cancer risk. 86 of them were control group and 98 were patients with esophageal cancer. DNA samples were genotyped by direct sequencing method and TaqMan allelic discrimination method. Statistical analysis was performed using GraphPad InStat™ Software and “Case-Control Study Estimating Calculator” from TAPOTILI company. A significant association was revealed between CCND1 homozygous genotype (А870A, OR=2.654) and TP53 heterozygous (Arg72Pro, OR=1.417) and homozygous (Pro72Pro, OR=2.860) genotypes increased risk of esophageal cancer. ru_RU
dc.language.iso en ru_RU
dc.subject Cancer ru_RU
dc.subject esophageal ru_RU
dc.subject polymorphism ru_RU
dc.subject CCND1 ru_RU
dc.subject TP53 ru_RU
dc.title TP53 Arg72Pro and CCND1 A870G Polymorphisms and Esophageal Cancer Risk ru_RU
dc.type Article ru_RU

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