Abstract:
In the present work, supramolecular complexes based on N- (diethylamino) benzylidenisone-kotinhydrazide and N- (2-bromo-3-phenyl) allylidenisononotinhydohydrazide and cyclodextrins (beta-CD, 2-GP-beta-CD) were first obtained and studied. Comparison of the integral intensities of the H-1 NMR signals of substrate (hydrazone) and beta- and 2-GP-beta-CD-beta receptors in supramolecular complexes showed that in all cases complexes of 1 guest molecule composition are formed for 2 host molecules. It was found that during the interaction they form an inclusion complex with the entry of the substrate molecule into the inner cavity of the receptor by the methylamine end. The resulting products form a mixture capable of dissolving in water or forming stable aqueous dispersions. The antiradical effect of synthesized supramolecular complexes on the DPPH radical was estimated. A concentration capable of 50% lowering the optical density of a 100 mu M solution of DPPH radical was determined. For a supramolecular complex based on N-(diethylamino)-benzylidenisonocinate-hydrazide and 2-GP-beta-cyclodextrin, IC50 (DPPH) was found to be 46.4 mu M
