Complexes of inclusion of functionally-substituted hydrasons of isonicothic acid with cyclodextrines and their antiradical activity

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dc.contributor.author Nurkenov, O.A.
dc.contributor.author Fazylov, S.D.
dc.contributor.author Issayeva, A.Zh.
dc.contributor.author Seilkhanov, T.M.
dc.contributor.author Zhivotova, T.S.
dc.contributor.author Shulgau, Z.T.
dc.contributor.author Kozhina, Zh.M.
dc.date.accessioned 2020-11-24T15:39:41Z
dc.date.available 2020-11-24T15:39:41Z
dc.date.issued 2018
dc.identifier.isbn DOI: 10.32014/2018.2518-1491.27
dc.identifier.issn 2518-1491
dc.identifier.issn 2224-5286
dc.identifier.uri http://repository.enu.kz:8080/handle/data/18334
dc.description.abstract In the present work, supramolecular complexes based on N- (diethylamino) benzylidenisone-kotinhydrazide and N- (2-bromo-3-phenyl) allylidenisononotinhydohydrazide and cyclodextrins (beta-CD, 2-GP-beta-CD) were first obtained and studied. Comparison of the integral intensities of the H-1 NMR signals of substrate (hydrazone) and beta- and 2-GP-beta-CD-beta receptors in supramolecular complexes showed that in all cases complexes of 1 guest molecule composition are formed for 2 host molecules. It was found that during the interaction they form an inclusion complex with the entry of the substrate molecule into the inner cavity of the receptor by the methylamine end. The resulting products form a mixture capable of dissolving in water or forming stable aqueous dispersions. The antiradical effect of synthesized supramolecular complexes on the DPPH radical was estimated. A concentration capable of 50% lowering the optical density of a 100 mu M solution of DPPH radical was determined. For a supramolecular complex based on N-(diethylamino)-benzylidenisonocinate-hydrazide and 2-GP-beta-cyclodextrin, IC50 (DPPH) was found to be 46.4 mu M ru_RU
dc.language.iso en ru_RU
dc.publisher News of the National Academy of Sciences of the Republic of Kazakhstan. Series of chemistry and technology ru_RU
dc.relation.ispartofseries Issue 6;Pages 57-66
dc.subject β-cyclodextrin ru_RU
dc.subject 2-hydroxypropyl-cyclodextrin ru_RU
dc.subject supramolecular inclusion complexes ru_RU
dc.subject antiradical activity ru_RU
dc.title Complexes of inclusion of functionally-substituted hydrasons of isonicothic acid with cyclodextrines and their antiradical activity ru_RU
dc.type Article ru_RU


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