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Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

dc.contributor.authorMukusheva, Gulim K.
dc.contributor.authorJalmakhanbetova, Roza I.
dc.contributor.authorShaibek, Altynay Zh.
dc.contributor.authorNurmaganbetova, Manshuk S.
dc.contributor.authorZhasymbekova, Aigerym R.
dc.contributor.authorNurkenov, Oralgazy A.
dc.contributor.authorAkishina, Ekaterina A.
dc.contributor.authorKolesnik, Irina A.
dc.contributor.authorDikusar, Evgenij A.
dc.contributor.authorTerpinskaya, Tatiana I.
dc.contributor.authorKulchitsky, Vladimir A.
dc.contributor.authorPotkin, Vladimir I.
dc.contributor.authorPushkarchuk, Alexander L.
dc.contributor.authorLyakhov, Dmitry A.
dc.contributor.authorMichels, Dominik L.
dc.date.accessioned2024-09-11T05:02:32Z
dc.date.available2024-09-11T05:02:32Z
dc.date.issued2024
dc.identifier.citationMukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; et al. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules 2024, 29, 3246. https://doi.org/10.3390/ molecules29143246ru
dc.identifier.issn1420-3049
dc.identifier.otherdoi.org/10.3390/molecules29143246
dc.identifier.urihttp://rep.enu.kz/handle/enu/16184
dc.description.abstractAlkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.ru
dc.language.isoenru
dc.publisherMoleculesru
dc.relation.ispartofseriesVolume 29;Issue 14
dc.subjectanabasineru
dc.subjectcytisineru
dc.subjectureasru
dc.subjectisoxazoleru
dc.subjectcytotoxic activityru
dc.subjectantiproliferative activityru
dc.subjectdrug synergismru
dc.subjectquantum chemical modelingru
dc.subjectmolecular dockingru
dc.titleAlkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cellsru
dc.typeArticleru


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