Changes in the Biochemical Parameters of Rat Blood under the Combined Effect of Chronic Intoxication with such Heavy Metals as Copper, Zinc, Arsenic

Abstract

The accelerated growth rates of cities, industrial development and mineral extraction have led to an increase in the volume of heavy metals entering the environment. The impact of heavy metals has been studied by many scientists, but there are still limited data on the complex effect of various heavy metals. Therefore, currently, there is an increasing interest in the effect of several heavy metals on living organisms. In this research, we modeled the chronic effects of three groups of heavy metals on the body of rats, as well as determined their biochemical parameters and changes in comparison with the control group. The results of our studies have shown that when combined with chronic intoxication with heavy metal salts, the biochemical indices of blood may vary, which is caused by a violation of the functions of the liver, kidneys, and heart muscle. Against the background of the toxic effects of heavy metals, we used “Ursodex” and “Schrot Rastoropshy” as helpful drugs for the organism, which contributed to a decrease in the toxicity of metals. The level of the negative effect of these elements on the biochemical indices of the blood of experimental animals decreased.