Biochemistry, Genetics and Molecul: Недавние поступления
Отображаемые элементы 21-40 из 139
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Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer’s Disease
(International Journal of Molecular Sciences, 2024)Although Alzheimer’s disease (AD) is traditionally viewed as a central nervous system disorder driven by the cerebral accumulation of toxic beta-amyloid (Aβ) peptide, new interpretations of the amyloid cascade hypothesis have led to the recognition of the dynamic equilibrium in which Aβ resides and the importance of peripheral Aβ production and degradation in maintaining ...2026-02-23 -
Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds
(Molecules, 2024)This study aimed to create new composite materials based on diatomite—a non-organic porous compound—through its surface modification with bioactive organic compounds, both synthetic and natural. Chloramphenicol, tetrahydroxymethylglycoluril and betulin were used as modifying substances. Composite materials were obtained by covering the diatomite surface with bioactive substance ...2026-02-23 -
Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes
(Molecular Biology and Evolution, 2025)Mitochondrial DNA (mtDNA) mutagenesis remains poorly understood despite its crucial role in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive 192-component mtDNA mutational spectrum for chordates by analyzing 118,397 synonymous mutations in the CytB gene across 1,697 species and five classes. This analysis revealed three primary forces ...2026-02-23 -
Draft genome sequence of two Fusobacterium varium strains isolated from patients in Kazakhstan with colorectal cancer
(Microbiology Resource Announcements, 2024)Fusobacterium varium is a Gram-negative, invasive, obligate anaerobe in the gastrointestinal tract microbiota, associated with various clinical conditions, including colorectal cancer (CRC). Here, we announce the draft genome sequence of two F. varium strains Fv36kaz and Fv63kaz from patients with CRC in Kazakhstan.2026-02-23 -
Isolation and Identification of Secondary Metabolites in Rheum tataricum L.fil. Growing in Kazakhstan and Surveying of Its Anticancer Potential
(Molecules, 2025)Turgunbayeva, A.A.; Sultanova, N.A.; Hamad, M.S.; Savelyev, V.A.; Chernyak, E.I.; Bagryanskaya, I.Y.; Pokrovsky, M.A.; Pokrovsky, A.G.; Gemejiyeva, N.G.; Shults, E.E. Isolation and Identification of Secondary Metabolites in Rheum tataricum L.fil. Growing in Kazakhstan and Surveying of Its Anticancer Potential. Molecules 2025, 30, 2978. https://doi.org/10.3390/ molecules301429782026-02-20 -
Influence of Geographical Locations on Drinking Water Quality in Rural Pavlodar Region, Kazakhstan
(Water, 2025)Drinking water quality in rural areas is impacted by industrial and agricultural runoff, water treatment infrastructure, and household economic conditions. This study explores the relationship between drinking water quality, water sources, and land cover types in northeastern Kazakhstan. The Water Quality Index (WQI) was calculated for each household and village using the ...2026-02-20 -
Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier
(Molecules, 2025)Hydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease of use, painlessness, increased efficiency due to prolongation of rheological, swelling and sorption characteristics, regulation of drug release, and stimulus sensitivity. Particular interest is shown in hydrogels of cellulose ether derivatives due to the possibility of obtaining ...2026-02-20 -
Gut microbiome-immune interactions and their role in rheumatoid arthritis development
(PeerJ, 2024)Objective: The primary objective is to study the impact of gut microbiota and their interactions with diverse immunological markers on the development of rheumatoid arthritis. Methods: This study was performed in Astana, Kazakhstan, and included 77 Kazakh female patients older than 18 years, who met the American College of Rheumatology 2010 classification criteria for ...2026-02-20 -
Green Synthesis of Silver Nanoparticles Using Circaea lutetiana Ethanolic Extract: Phytochemical Profiling, Characterization, and Antimicrobial Evaluation
(International Journal of Molecular Sciences, 2025)In the current decade, the use of plant extracts for the green preparation of metal nanoparticles has garnered increasing attention due to their eco-friendliness, costeffectiveness, and sustainability. In the current study, silver nanoparticles (AgNPs) were synthesized using the ethanolic extract of Circaea lutetiana for the first time. Thetotal flavonoid content (TFC) and ...2026-02-20 -
Genome sequence and assembly of the amylolytic Bacillus licheniformis T5 strain isolated from Kazakhstan soil
(BMC Genomic Data, 2024)Objectives The data presented in this study were collected with the aim of obtaining the complete genomes of specifc strains of Bacillus bacteria, namely, Bacillus licheniformis T5. This strain was chosen based on its enzymatic activities, particularly amylolytic activity. In this study, nanopore sequencing technology was employed to obtain the genome sequences of this strain. ...2026-02-20 -
Genetic Polymorphism of Y-Chromosome in Turkmen Population from Turkmenistan
(Genes, 2024)This study investigates the Y-chromosome genetic diversity of the Turkmen population in Turkmenistan, analyzing 23 Y-STR loci for the first time in a sample of 100 individuals. Combined with comparative data from Turkmen populations in Afghanistan, Iran, Iraq, Russia, and Uzbekistan, this analysis offers insights into the genetic structure and relationships among Turkmen ...2026-02-20 -
Genetic Diversity and Ethnic Tapestry of Kazakhstan as Inferred from HLA Polymorphism and Population Dynamics: A Comprehensive Review
(Genes, 2025)The human leukocyte antigen (HLA) system represents the most polymorphic segment within human DNA sequences and constitutes a core component of immune defense responses and in understanding population genetics. This research investigates the distribution of HLA class I and II polymorphisms across different ethnic groups in Kazakhstan, offering valuable insights into the genetic ...2026-02-20 -
Gene Expression Changes in the Spleen, Lungs, and Liver of Wistar Rats Exposed to β-Emitted 31SiO2 Particles
(International Journal of Molecular Sciences, 2025)To understand the biological effects of residual radioactivity after the atomic bomb explosion in Hiroshima and Nagasaki, we previously investigated the effects of 56Mn, a major residual radioisotope. Our rat study demonstrated that inhalation exposure to 56MnO2 microparticles affected gene expression in the lungs, testes, and liver, despite the low radiation doses. Because ...2026-02-20 -
Whole genome sequencing and de novo genome assembly of the Kazakh native horse Zhabe
(Frontiers in Genetics, 2024)The horse (Equus caballus) is a domesticated animal with great significance in human civilization and history, having played a crucial role in transportation, agriculture, and warfare. Over millennia, intentional breeding has resulted in the creation of approximately 500 distinct horse breeds, each selected for specific performance qualities, appearance, and behavior (Petersen ...2026-02-20 -
Fermentation Conditions of Lactobacilli for the Production of Lactose-Free Starter Culture
(OnLine Journal of Biological Sciences, 2024)This research aims to determine the fermentation conditions and viability in a medium simulating the gastrointestinal tract and to examine the antagonistic potential of Lactobacillus acidophilus (Lb. acidophilus) and Lactobacillus rhamnosus (Lb. rhamnosus) in producing a lactose-free starter. Our study examined Lactic Acid Bacteria (LAB). The sources of Lb. acidophilus ...2026-02-20 -
Development of an Ankle Exoskeleton: Design, Modeling, and Testing
(Sensors, 2025)This research presents the results of conceptual design and modeling of an exoskeleton. It is intended for ankle joint rehabilitation in patients with musculoskeletal disorders. The exoskeleton design includes three screw actuators that smoothly control motion in the planes of dorsal and plantar flexion, inversion, and eversion. The results of the virtual tests performed on ...2026-02-20 -
Design, Simulation and Functional Testing of a Novel Ankle Exoskeleton with 3DOFs
(Sensors, 2024)This paper presents a study on developing a new exoskeleton for ankle joint rehabilitation with three degrees of freedom (3 DOFs). The primary attention is paid to the process of designing and modelling the device aimed at restoring the lost functions of joint mobility. The authors conducted a complex analysis of the functional requirements of the exoskeleton based on research ...2026-02-20 -
Cybersecurity Solutions for Industrial Internet of Things–Edge Computing Integration: Challenges, Threats, and Future Directions
(Sensors, 2025)This paper provides the complete details of current challenges and solutions in the cybersecurity of cyber-physical systems (CPS) within the context of the IIoT and its integration with edge computing (IIoT–edge computing). We systematically collected and analyzed the relevant literature from the past five years, applying a rigorous methodology to identify key sources. Our ...2026-02-20 -
Cellulose-Based Sorbents: A Comprehensive Review of Current Advances in Water Remediation and Future Prospects
(Molecules, 2024)Cellulose-based sorbents are promising materials for wastewater treatment due to their environmental friendliness, biodegradability, and high sorption capacity. This paper presents an overview of cellulose modification methods, including carboxylation, amination, oxidation, graphene, and plasma treatments, as well as combined approaches. Their effect on key physicochemical ...2026-02-20 -
Atomistic Modeling of Natural Gas Desulfurization Process Using Task-Specific Deep Eutectic Solvents Supported by Graphene Oxide
(Molecules, 2024)This study employs Density Functional Theory (DFT) calculations and traditional allatom Molecular Dynamics (MD) simulations to reveal atomistic insights into a task-specific Deep Eutectic Solvent (DES) supported by graphene oxide with the aim of mimicking its application in the natural gas desulfurization process. The DES, composed of N,N,N′ ,N′ -tetramthyl-1,6-hexane diamine ...2026-02-20
