Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells
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Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; et al. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules 2024, 29, 3246. https://doi.org/10.3390/ molecules29143246
Аннотации
Alkaloid-based urea derivatives were produced with high yield through the reaction of
anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity,
in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil,
etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the
quantum chemical calculations data and molecular docking, hypotheses have been put forward to
explain their mutual influence when affecting C6 rat glioma model cells.
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