Asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) has attracted great interest in recent years due to the poor knowledge of its mechanisms, difficulties in differential diagnosis and control. The purpose of this study was to investigate the characteristics of immunological changes in patients with ACOS. The study groups consisted of 22 people with COPD, 13 ...

The present review describes the benefical effects of diatomite ( siliceous skeletons of archaic microscopic algae – diatomei) application for improving the plant tolerance to drought and salinity. There are numerous publications on the role of diatomite in mechanical and chemical protection of plants against unfavorable environmental conditions, however, the mechanisms of ...

The paper provides an overview of the use of various betulin derivatives. There are represented conclusions of in-silico research of betulin, betulinic acid, betulinic diacetate, allobetulinol. There has been used OSIRIS software for in silico analysis PASS, Molinspiration. Obtained results of the study show that after summarizing of all forecasts betulin and betulinic acid ...

On the territory of the Almaty region, there are warehouses with banned and nonutilized pesticides, the active substances, and metabolites of which pollute the pastures of farm animals located nearby. Blood samples of 27 sheep from three monitoring points of the Almaty region were analyzed for the presence of genomic mutations and chromosomal aberrations. Cell cultivation and ...

Exosomes are extracellular vesicles secreted by almost all cell types that can function as a cell-to-cell carrier of information, providing pleiotropic functions in intercellular communication. Exosomes can transport various biomolecules, including proteins and nucleic acids, into recipient cells. The review analyzed the current data on the role of exosomes and the possibility ...

The work studied the general ecological state of Lake Bolshoy Sarykol in the east of the Abay district of Karaganda region. Morphometric measurements of the reservoir, studies of samples for hydrochemical composition, composition of bottom sediments, diversity and quantitative indicators of coastal aquatic vegetation, diversity and quantitative indicators of phyto- and ...

Nowadays a number of nations are exploring differences in gene expression resulting from changes in DNA methylation and modification of chromatin structure in response to external stimuli, such as radiation. It has been also well known that Ionizing radiation affects variety processes in exposed cells, in particular, cause changes in gene expression, mitochondria metabolic activity, ...

This paper presents the results of the research on macrophytes of floodplain swamps of the coastal territories of the Aktastinka River and wetlands of Aktasty village, located in Arshalinsky district, Akmola region of the Republic of Kazakhstan. The inventory revealed the floristic composition of the Aktastinka village locality and the coastal territory. Along with species ...

Asthma is a complex heterogeneous disease, the development of which is determined by the complex interaction of many predisposition genes and environmental factors. Many epidemiological studies have shown that single nucleotide polymorphism (SNP) in the FCER1B (rs1441586), FCER2 (28364072), and ADAM33 (rs528557) genes are associated with the risk development of asthma. However, ...

The present article provides a comparative analysis of the morphofunctional indicators of 13–15 year old girls of different types of constitution, living in the cities of Pavlodar and Kyzylorda. Most of the studied schoolgirls belonged to the thoracic and muscular types of constitution. Considerable attention is paid to the comparison of such morphological parameters as body ...