http://repository.enu.kz/handle/enu/1138 2026-04-04T01:59:41Z 2026-04-04T01:59:41Z Akbayeva, L.Kh. Pangaliyaev, E.M. Atasoy, E. Mamytova, N.S. Kobetayeva, N.K. http://repository.enu.kz/handle/enu/1141 2025-06-13T20:33:37Z 2022-01-01T00:00:00Z

Dynamics of changes in air temperature and precipitation in the Karaganda region Akbayeva, L.Kh.; Pangaliyaev, E.M.; Atasoy, E.; Mamytova, N.S.; Kobetayeva, N.K. The article examines the long-term variability of a number of meteorological parameters in the Karaganda region. It analyzes reliable data from the site "Climate and Weather" of the international databases SYNOP and METAR. The average annual air temperature and precipitation for 1940-2020 were studied using the linear trend method. The results showed that the climate of the Karaganda region changed significantly between 1940-2020, both in temperature and precipitation. Over 80 years, the average annual temperature has increased by 1.1 ° C, which is high for the short term. Due to the warming of winter, the climate of the region has warmed up, and the average annual precipitation has increased by 145 mm.

2022-01-01T00:00:00Z Aripova, A.A. Bissarina, T.B. Bulgakova, O.V. Kussainova, A.A. Bersimbaev, R.I. http://repository.enu.kz/handle/enu/1140 2025-06-13T23:41:30Z 2022-01-01T00:00:00Z

Study the level of thymus stromal lymphopoietin in the blood of persons exposed to asbestos Aripova, A.A.; Bissarina, T.B.; Bulgakova, O.V.; Kussainova, A.A.; Bersimbaev, R.I. . Asbestos dust is classified as a carcinogen by the International Agency for Research on Cancer. Asbestos particles, binding cations, leach the cell environment. The initiation of the release of dust particles activates the NF-kB signaling cascade, which in turn includes the synthesis of pro-inflammatory cytokines, such as thymus stromal lymphopoietin (TSLP). The increased level of these cytokines is directly related to malignant processes in the body. The aim of the study is to study the level of TSLP in the blood serum of people exposed to asbestos. The material for the study was cytokines isolated from the blood serum of 40 exposed to asbestos and 50 healthy people. Peripheral blood samples were collected from workers of the Zhitikara asbestos mining company of the city of Kostanay. The content of the main TSLP levels in blood serum was determined by ELISA the Human TSLP ELISA Kit (Biorbyt Ltd, UK, No. orb138077). The optical density of the reaction products was determined using a spectrophotometer with a wavelength of 450 nm. The concentration of TSLP in the blood serum were increased 3 times in persons exposed to asbestos compared to the control group (p = 0.000011). The concentration of the level of TSLP can serve as a diagnostic biomarker of a number of diseases that are induced by asbestos.

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