Просмотр по автору "Efimenko, Bogdan"

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    • Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes 

      Iliushchenko, Dmitrii; Efimenko, Bogdan; Mikhailova, Alina G.; Shamanskiy, Victor; Saparbaev, Murat K.; Matkarimov, Bakhyt T.; Mazunin, Ilya; Voronka, Alexandr; Knorre, Dmitry; Kunz, Wolfram S.; Kapranov, Philipp; Gunbin; Popadin, Konstantin (Molecular Biology and Evolution, 2025)
      Mitochondrial DNA (mtDNA) mutagenesis remains poorly understood despite its crucial role in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive 192-component mtDNA mutational spectrum for chordates by analyzing 118,397 synonymous mutations in the CytB gene across 1,697 species and five classes. This analysis revealed three primary forces ...
      2026-01-19

    • Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes 

      Iliushchenko, Dmitrii; Efimenko, Bogdan; Mikhailova, Alina G.; Shamanskiy, Victor; Saparbaev, Murat K.; Matkarimov, Bakhyt T.; Mazunin, Ilya; Voronka, Alexandr; Knorre, Dmitry; Kunz, Wolfram S.; Kapranov, Philipp; Denisov, Stepan; Fellay, Jacques; Khrapko, Konstantin; Gunbin, Konstantin; Popadin, Konstantin (Molecular Biology and Evolution, 2025)
      Mitochondrial DNA (mtDNA) mutagenesis remains poorly understood despite its crucial role in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive 192-component mtDNA mutational spectrum for chordates by analyzing 118,397 synonymous mutations in the CytB gene across 1,697 species and five classes. This analysis revealed three primary forces ...
      2026-02-23