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1D and 2D NMR spectroscopy for identification of carbamide-containing biologically active compounds

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dc.contributor.author Bakibaev, A.A.
dc.contributor.author Panshina, S.Yu.
dc.contributor.author Ponomarenko, O.V.
dc.contributor.author Malkov, V.S.
dc.contributor.author Kotelnikov, O.A.
dc.contributor.author Tashenov, A.K.
dc.date.accessioned 2024-09-18T05:12:42Z
dc.date.available 2024-09-18T05:12:42Z
dc.date.issued 2021
dc.identifier.citation Bakibaev, A.A., Panshina, S.Yu., Ponomarenko, O.V., Malkov, V.S., Kotelnikov, O.A., & Tashenov, A.K. 1D and 2D NMR spectroscopy for identification of carbamide-containing biologically active compounds. Bulletin of the University of Karaganda – Chemistry, 101(1), 71-81. https://doi.org/10.31489/2021Ch1/71-81 ru
dc.identifier.issn 2518718X
dc.identifier.other doi.org/10.31489/2021Ch1/71-81
dc.identifier.uri http://rep.enu.kz/handle/enu/16555
dc.description.abstract Urea (carbamide) is the main end product of amino acids' metabolism in mammals. Extensive research in the field of urea chemistry has contributed to the creation of many biologically active and other compounds based on the carbamide fragment NH–CO–NH. The substituting groups of urea directly affect its properties and characteristics which are reflected in the NMR spectral data and this circumstance can be the basis for the identification of urea derivatives. In this work, chemical shifts in the NMR spectra of urea and its acyclic structure, barbituric series, imidazolidinone series and bicyclic structure derivatives were studied and identified. A system analysis was carried out to determine the effect of the type of substituents on the positions of signals of the NH-CO-NH fragment in the NMR spectra. The possibility of 2D NMR spectroscopy using to simplify the identification procedure for complex mixtures was shown in the paper. The combined use of 1D and 2D NMR spectroscopy is convenient and informative to establish the structure of biologically active compounds. These methods make it possible to determine the presence and type of impurities, as well as to establish the destruction processes leading to the corresponding impurities. ru
dc.language.iso en ru
dc.publisher Bulletin of the Karaganda University Chemistry Series ru
dc.relation.ispartofseries Том 17, Выпуск 1,;Страницы 71 - 81
dc.subject urea ru
dc.subject urea-containing compounds ru
dc.subject barbiturates ru
dc.subject glycoluril ru
dc.subject imidazolidinone ru
dc.subject NMR spectroscopy ru
dc.subject hydrolysates ru
dc.subject impurities ru
dc.title 1D and 2D NMR spectroscopy for identification of carbamide-containing biologically active compounds ru
dc.type Article ru


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