Comparative analysis of immunoglobulins in case of combined exposure of dust-radiation factors at remote period

Abstract

One of the most radiosensitive functions of human and animals body is immunological reactivity. A characteristic feature of the radiation exposure is the long-term preservation of damages in individual links of the immune system and associated remote effects and complications. Recently, particular interest is the combined effect of radiation and non-radiation factors on the immune system. In our example, coal dust and various doses of radiation in a remote period had been considered. The aim of this research was to study the effect of low and sublethal doses of irradiation and coal dust, as well as in separate and in combined effects to the immunoglobulin indices in animals in experimental conditions at remote periods. Six series of experiments had been performed on 60 male rats of Wistar line: group I - intact, group II - rats that inhaled coal dust, group III – exposed to gamma irradiation in a dose 0.2 Gy, IV – exposed to gamma irradiation in a dose of 6 Gy, V group – experienced the combined effect of low dose of radiation and coal dust, VI group - exposed to the combined effect of sublethal dose of radiation and coal dust. Analysis of the researsh results showed that rats exposed to combined dust-radiation factor at remote period had significant changes, which were characterized with the decrease of Ig A and Ig G and increase of Ig M. Ionizing radiation in combination with coal dust at the remote period had more apparent effects, and dominant agent was ionizing radiation.