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Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats

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dc.contributor.author Fujimoto, Nariaki
dc.contributor.author Amantayeva, Gaukhar
dc.contributor.author Chaizhunussova, Nailya
dc.contributor.author Shabdarbayeva, Dariya
dc.contributor.author Abishev, Zhaslan
dc.contributor.author Ruslanova, Bakhyt
dc.contributor.author Zhunussov, Yersin
dc.contributor.author Azhimkhanov, Almas
dc.contributor.author Zhumadilov, Kassym
dc.contributor.author Petukhov, Aleksey
dc.contributor.author Stepanenko, Valeriy
dc.contributor.author Hoshi, Masaharu
dc.date.accessioned 2024-09-20T10:37:25Z
dc.date.available 2024-09-20T10:37:25Z
dc.date.issued 2020
dc.identifier.issn 1422-0067
dc.identifier.other doi:10.3390/ijms21144989
dc.identifier.uri http://rep.enu.kz/handle/enu/16767
dc.description.abstract To investigate the biological effects of internal exposure of radioactive 56MnO2 powder, the major radioisotope dust in the soil after atomic bomb explosions, on male reproductive function, the gene expression of the testes and the prostate was examined. Ten-week-old male Wistar rats were exposed to three doses of radioactive 56MnO2 powder (41–100 mGy in whole body doses), stable MnO2 powder, or external 60Co γ-rays (2 Gy). Animals were necropsied on Days 3 and 61 postexposure. The mRNA expressions of testicular marker protein genes and prostatic secretory protein genes were quantified by Q-RT-PCR. On Day 3 postexposure, the testicular gene expressions of steroidogenesis-related enzymes, Cyp17a1 and Hsd3b1, decreased in 56MnO2-exposed groups. Germ cell-specific Spag4 and Zpbp mRNA levels were also reduced. On postexposure Day 61, the Cyp11a1 gene expression became significantly reduced in the testes in the group exposed to the highest dose of 56MnO2, while another steroidogenesis-related StAR gene mRNA level reduced in the 60Co γ-rays group. There were no differences in Spag4 and Zpbp mRNA levels among groups on Day 61. No histopathological changes were observed in the testes in any group following exposure. Expression in the prostatic protein genes, including CRP1, KS3, and PSP94, significantly decreased in 56MnO2-exposed groups as well as in the 60Co γ-rays group on Day 61 postexposure. These data suggest that the internal exposure to 56MnO2 powder, at doses of less than 100 mGy, affected the gene expressions in the testis and the prostate, while 2 Gy of external γ-irradiation was less effective. ru
dc.language.iso en ru
dc.publisher International Journal of Molecular Sciences ru
dc.relation.ispartofseries Volume 21 Issue 14;
dc.subject residual radiation ru
dc.subject internal radiation exposure ru
dc.subject radiation injury ru
dc.subject testis ru
dc.subject prostatic function ru
dc.subject rat ru
dc.title Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats ru
dc.type Article ru


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