Conceived and designed experiments: Sarbassov DD; Performed the cell culture and mouse studies: Wu X; Supported the xenograft study: Park M, Song MS; Optimized the drug injections: Sarbassova DA; Wrote the manuscript: Sarbassova DD, Song MS, Sarbassova DA; Supported the pancreatic cancer cell study: Ying H; Supported the colorectal cancer cell study: Bhattacharya R, Ellis ...

Among the three active aldehyde oxidases in Arabidopsis thaliana leaves (AAO1-3), AAO3, which catalyzes the oxidation of abscisic-aldehyde to abscisic-acid, was shown recently to function as a reactive aldehyde detoxifier. Notably, aao2KO mutants exhibited less senescence symptoms and lower aldehyde accumulation, such as acrolein, benzaldehyde, and 4-hydroxyl-2-nonenal (HNE) ...

The physicochemical properties of natural bentonite and its sorbents were studied. It has been established the modification of natural bentonites using polyhydroxoxides of iron (III) (mod.1_Fe_5-c) and aluminum (III) (mod.1_Al_5-c) by the “co-precipitation” method led to changes in their chemical composition, structure, and sorption properties. It was shown that modified sorbents ...

Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based ...

Industrial Internet of things (IIoT) environments need to implement reliable security measures because of the growth in network traffic and overall connectivity. Accordingly, this work provides the architecture of network traffic analysis and the detection of intrusions in a network with the help of edge computing and using machine-learning methods. The study uses k-means and ...

This research investigates the improvement of learning systems that utilize avatars by shifting from elementary language compatibility to emotion-driven interactions. An assessment of various instructional approaches indicated marked differences in overall effectiveness, with the system showing steady but slight improvements and little variation, suggesting it has the potential ...

This paper presents the results of a study of polyethylene terephthalate (PET) films irradiated with Ar and Kr ions at both normal orientation and an angle of 40◦ to the normal. Normal irradiation was performed using Ar8+ and Kr15+ ions with an energy of 1.75 MeV/au and fluences in the range (2–500) × 1010 cm−2 for Ar8+ ions and (1.6 − 6.5) × 1010 cm−2 for Kr15+ ions. Kr ions ...

This study employs Density Functional Theory (DFT) calculations and traditional allatom Molecular Dynamics (MD) simulations to reveal atomistic insights into a task-specific Deep Eutectic Solvent (DES) supported by graphene oxide with the aim of mimicking its application in the natural gas desulfurization process. The DES, composed of N,N,N′ ,N′ -tetramthyl-1,6-hexane diamine ...

In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe3O4 ...

The production of activated carbon (AC) from lignocellulosic biomass through chemical activation is gaining global attention due to its scalability, economic viability, and environmental advantages. Chemical activation offers several benefits, including energy efficiency, reduced carbonization time, and lower temperature requirements. In this study, potassium hydroxide (KOH) was ...