ПросмотрBiochemistry, Genetics and Molecul по теме "Alzheimer’s disease"

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    • Distinctive Effects of Fullerene C60 and Fullerenol C60(OH)24 Nanoparticles on Histological, Molecular and Behavioral Hallmarks of Alzheimer’s Disease in APPswe/PS1E9 Mice 

      Askarova, Sholpan; Sitdikova, Kseniia; Kassenova, Aliya; Chaprov, Kirill; Svirin, Evgeniy; Tsoy, Andrey; Munter, Johannes de; Gorlova, Anna; Litavrin, Aleksandr; Deikin, Aleksei; Nedorubov, Andrey; Appazov, Nurbol; Kalueff, Allan; Chernopiatko, Anton; Strekalova, Tatyana (Antioxidants, 2025)
      Fullerenes and fullerenols exhibit antioxidant and anti-inflammatory properties, making them promising candidates for Alzheimer’s disease (AD) therapy. Unlike conventional anti-inflammatory drugs, these compounds have multitargeted effects, including their ability to inhibit amyloid fibril formation. However, few studies have explored their efficacy in high-validity AD models. ...
      2026-02-20

    • Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer’s Disease 

      Tsoy, Andrey; Umbayev, Bauyrzhan; Kassenova, Aliya; Kaupbayeva, Bibifatima; Askarova, Sholpan (International Journal of Molecular Sciences, 2024)
      Although Alzheimer’s disease (AD) is traditionally viewed as a central nervous system disorder driven by the cerebral accumulation of toxic beta-amyloid (Aβ) peptide, new interpretations of the amyloid cascade hypothesis have led to the recognition of the dynamic equilibrium in which Aβ resides and the importance of peripheral Aβ production and degradation in maintaining ...
      2026-02-23