• Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells 

      Mukusheva, Gulim K.; Jalmakhanbetova, Roza I.; Shaibek, Altynay Zh.; Nurmaganbetova, Manshuk S.; Zhasymbekova, Aigerym R.; Nurkenov, Oralgazy A.; Akishina, Ekaterina A.; Kolesnik, Irina A.; Dikusar, Evgenij A.; Terpinskaya, Tatiana I.; Kulchitsky, Vladimir A.; Potkin, Vladimir I.; Pushkarchuk, Alexander L.; Lyakhov, Dmitry A.; Michels, Dominik L. (Molecules, 2024)
      Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based ...
      2024-09-11
    • Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells 

      Mukusheva, Gulim K.; Jalmakhanbetova, Roza I.; Shaibek, Altynay Zh.; Nurmaganbetova, Manshuk S.; Zhasymbekova, Aigerym R.; Nurkenov, Oralgazy A.; Akishina, Ekaterina A.; Kolesnik, Irina A.; Dikusar, Evgenij A.; Terpinskaya, Tatiana I.; Kulchitsky, Vladimir A.; Potkin, Vladimir I.; Pushkarchuk, Alexander L.; Lyakhov, Dmitry A.; Michels, Dominik L. (Molecules, 2024)
      Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based ...
      2026-02-20