EFFICACY OF PRECONDITIONED HUMAN UMBILICAL CORD BLOOD MESENCHYMAL STEM CELLS IN A MOUSE MODEL OF PSORIASIS

Abstract

The article presents a study on the therapeutic effect of intact and preconditioned human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) in a mouse model of imiquimod (IMQ)-induced psoriasis-like skin inflammation. Both intact and preconditioned hUCB-MSCs effectively reduced skin inflammation. hUCB-MSCs preconditioned with IL-22 and TNF-α showed significant improvement in erythema and scaling, while hUCB-MSCs preconditioned with IL-17A, IL-22, and TNF-α significantly reduced skin thickness. These findings demonstrate the strong antiinflammatory and regenerative potential of hUCB-MSCs, supporting their therapeutic value for psoriasis treatment.