EFFICACY OF PRECONDITIONED HUMAN UMBILICAL CORD BLOOD  MESENCHYMAL STEM CELLS IN A MOUSE MODEL OF PSORIASIS

dc.contributor.author	Dairov, Aidar Kuanyshbekovich
dc.date.accessioned	2026-04-13T09:59:52Z
dc.date.available	2026-04-13T09:59:52Z
dc.date.issued	2025
dc.identifier.isbn	978-601-08-5373-7
dc.identifier.uri	http://repository.enu.kz/handle/enu/31621
dc.description.abstract	The article presents a study on the therapeutic effect of intact and preconditioned human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) in a mouse model of imiquimod (IMQ)-induced psoriasis-like skin inflammation. Both intact and preconditioned hUCB-MSCs effectively reduced skin inflammation. hUCB-MSCs preconditioned with IL-22 and TNF-α showed significant improvement in erythema and scaling, while hUCB-MSCs preconditioned with IL-17A, IL-22, and TNF-α significantly reduced skin thickness. These findings demonstrate the strong antiinflammatory and regenerative potential of hUCB-MSCs, supporting their therapeutic value for psoriasis treatment.	ru
dc.language.iso	en	ru
dc.publisher	L.N. Gumilyov Eurasian National University	ru
dc.subject	mesenchymal stem cell	ru
dc.subject	human umbilical cord blood mesenchymal stem cell	ru
dc.subject	cytokine	ru
dc.subject	psoriasis	ru
dc.subject	skin inflammation	ru
dc.title	EFFICACY OF PRECONDITIONED HUMAN UMBILICAL CORD BLOOD MESENCHYMAL STEM CELLS IN A MOUSE MODEL OF PSORIASIS	ru
dc.type	Article	ru