Abstract:
The article presents a study on the therapeutic effect of intact and preconditioned
human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) in a mouse model of imiquimod
(IMQ)-induced psoriasis-like skin inflammation. Both intact and preconditioned hUCB-MSCs
effectively reduced skin inflammation. hUCB-MSCs preconditioned with IL-22 and TNF-α showed
significant improvement in erythema and scaling, while hUCB-MSCs preconditioned with IL-17A,
IL-22, and TNF-α significantly reduced skin thickness. These findings demonstrate the strong antiinflammatory and regenerative potential of hUCB-MSCs, supporting their therapeutic value for
psoriasis treatment.
